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Updated: May 14, 2026

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
Published on: May 21, 2012
Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense
Julia Farache1, Ehud Zigmond, Guy Shakhar
1Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Abstract:
Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103(+) dendritic cells and CX3CR1(+) macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).
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