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Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
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Greater neuronal responses during automatic semantic processing in schizophrenia.

Lisa B Wilson1, Donald C Rojas, Shireen Shatti

  • 1Department of Psychiatry, University of Colorado Denver, Aurora 80045, USA. lisa.wilson@ucdenver.edu

Neuroreport
|February 13, 2013
PubMed
Summary
This summary is machine-generated.

Individuals with schizophrenia show different brain activity during semantic priming tasks compared to healthy individuals. This study reveals enhanced brain responses in schizophrenia, suggesting prolonged automatic spreading activation.

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Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Psychiatric Disorders

Background:

  • Schizophrenia is characterized by disturbed associative processes.
  • Previous functional MRI studies have not adequately examined automatic semantic priming in schizophrenia.
  • Understanding automatic semantic processing is crucial for identifying associative disturbances in schizophrenia.

Purpose of the Study:

  • To investigate hemodynamic responses during indirect semantic priming in schizophrenia.
  • To assess automatic spreading activation using a short stimulus onset asynchrony (350 ms).
  • To explore associative disturbances in schizophrenia through functional MRI.

Main Methods:

  • Seventeen individuals with schizophrenia and 15 comparison participants underwent functional MRI.
  • Participants performed a lexical decision task with related, unrelated, and word/nonword pairs.
  • A region of interest analysis focused on temporal and frontal brain regions.

Main Results:

  • Comparison participants showed hemodynamic suppression during priming.
  • Individuals with schizophrenia exhibited hemodynamic enhancement in response to priming.
  • Enhanced responses were observed in the left fusiform and superior temporal gyri in schizophrenia patients for indirectly related words.

Conclusions:

  • Schizophrenia is associated with altered hemodynamic responses during semantic priming.
  • Enhanced temporal lobe responses in schizophrenia may indicate increased and prolonged automatic spreading activation.
  • These findings provide insights into the neurobiological underpinnings of associative disturbances in schizophrenia.