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Drug-protein interactions. Comparative studies of levamisole and structural analogs or agents with immunomodulatory
M Chicault1, C Luu-Duc, A Boucherle
1Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.
Arzneimittel-Forschung
|January 1, 1990
Abstract:
Interactions of tetramisole, imidazo[2,1-b]thiazolic derived or immunomodulatory agents with human serum albumin (HSA) and immunoglobulins G and A has been investigated in vitro using polyacrylamide gel electrophoresis and immunoelectrophoresis. The results suggest that only the chemical structure type of tetramisole is able to induce a protein-protein interaction described as a mechanism of disulfide-sulfhydryl interchange reactions. The groups of atoms involved in the interaction are characterized.