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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Tuberous sclerosis complex in autism.

Xin Guo¹, Wen-Jun Tu, Xiao-Dong Shi

¹Department of Clinical laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Iranian Journal of Pediatrics

|February 13, 2013

Summary

Tuberous sclerosis complex (TSC) affects 1.17% of children with autistic disorder. This neurocutaneous disorder is linked to developmental delays and intellectual disability in affected children.

Keywords:

Autism Autistic Disorder Neurocutaneous Syndromes Tuberous Sclerosis Complex

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Area of Science:

Neuroscience
Genetics
Developmental Pediatrics

Background:

Autistic disorder is a complex neurodevelopmental condition.
Tuberous sclerosis complex (TSC) is a genetic disorder with neurological manifestations.
The co-occurrence and prevalence of TSC in individuals with autistic disorder require further investigation.

Purpose of the Study:

To determine the prevalence rate of tuberous sclerosis complex (TSC) among children diagnosed with autistic disorder.
To investigate potential associations between autistic disorder and the development of TSC.

Main Methods:

A cohort of 429 children diagnosed with autistic disorder and pervasive developmental disorders was followed from 2005 to 2009.
Children were routinely screened for neurocutaneous markers of TSC, such as depigmented spots.
Individuals with infantile spasms or epilepsy underwent regular monitoring for TSC clinical features.

Main Results:

Five children in the cohort were diagnosed with tuberous sclerosis complex (TSC), indicating a prevalence of 1.17%.
All children with co-occurring TSC and autistic disorder exhibited moderate to severe mental retardation, with IQ or developmental quotients below 70.

Conclusions:

The prevalence of tuberous sclerosis complex (TSC) in autistic disorder was found to be 1.17% in the studied region.
Autistic disorder may be associated with an increased risk for the development of tuberous sclerosis complex (TSC).