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Updated: May 14, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Screening test for malignant hyperthermia in patients with persistent hyperCKemia: a pilot study.

Stephan Johannsen1, Christina Berberich, Thomas Metterlein

  • 1Department of Anaesthesia and Critical Care, University of Wuerzburg, Oberduerrbacher Strasse 6, D-97080 Wuerzburg, Germany.

Muscle & Nerve
|February 13, 2013
PubMed
Summary

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A new microdialysis test accurately identifies malignant hyperthermia (MH) susceptibility in patients with high creatine kinase (CK) levels. This minimally invasive method offers a safer alternative to muscle biopsy for diagnosing MH predisposition.

Area of Science:

  • Anesthesiology
  • Clinical Biochemistry
  • Muscle Physiology

Background:

  • Persistent elevation of serum creatine kinase (CK) is linked to malignant hyperthermia (MH) susceptibility.
  • Diagnosing MH susceptibility often involves invasive procedures like surgical muscle biopsy.
  • A minimally invasive metabolic test could provide a safer diagnostic alternative.

Purpose of the Study:

  • To evaluate the efficacy of a microdialysis-based metabolic test for diagnosing MH susceptibility.
  • To determine if hyperCKemia affects the test's diagnostic accuracy.

Main Methods:

  • Thirty-nine participants were enrolled: 10 MH susceptible (MHS), 21 MH non-susceptible (MHN), and 8 MHN with persistent hyperCKemia (>500 U/L).
  • Microdialysis probes were inserted into the vastus lateralis muscle.

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  • Halothane or caffeine was administered locally, and lactate concentrations in dialysis samples were measured.

    • Main Results:

    • Baseline lactate levels were comparable across all participant groups.
    • A significant increase in lactate concentration was observed exclusively in the MHS group following halothane or caffeine administration.
    • The test results were not influenced by the presence of hyperCKemia.

    Conclusions:

    • The microdialysis test effectively differentiates MH susceptible individuals from non-susceptible ones, even in the presence of elevated CK levels.
    • This minimally invasive test may serve as a valuable screening tool for MH susceptibility in patients with persistent hyperCKemia.
    • Microdialysis offers a potentially safer alternative to surgical muscle biopsy for diagnosing MH susceptibility.