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Retinal nerve fiber layer thickness in benign multiple sclerosis.

Alex P Lange1, Feng Zhu, Ana-Luiza Sayao

  • 1Neuro-Ophthalmology, Department of Ophthalmology, University of British Columbia, Canada.

Multiple Sclerosis (Houndmills, Basingstoke, England)
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PubMed
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Retinal nerve fiber layer (RNFL) thickness is reduced in benign multiple sclerosis (MS) patients compared to healthy individuals. This thinning is linked to optic neuritis history but not disability or disease duration in MS.

Keywords:
Spectral domain optical coherence tomographyretinal nerve

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Area of Science:

  • Ophthalmology
  • Neurology
  • Neuroscience

Background:

  • Retinal nerve fiber layer (RNFL) thickness is associated with brain atrophy in multiple sclerosis (MS).
  • Limited data exists on retinal atrophy in benign MS.
  • This study investigates RNFL thickness in benign MS.

Purpose of the Study:

  • To compare RNFL thickness in benign MS patients with healthy controls.
  • To explore the relationship between RNFL thickness and MS characteristics.

Main Methods:

  • Recruited 29 benign MS patients (EDSS ≤ 3, disease duration ≥15 years) and 29 age-matched healthy controls.
  • Measured RNFL thickness using spectral-domain optical coherence tomography.
  • Employed ANOVA and linear mixed-effects models for statistical analysis.

Main Results:

  • Benign MS eyes showed significantly lower RNFL thickness than healthy controls (p<0.02).
  • RNFL thickness was associated with a history of optic neuritis (p<0.0001).
  • No association found between RNFL thickness, EDSS, or disease duration (p>0.1).

Conclusions:

  • Patients with benign MS exhibit reduced RNFL thickness compared to healthy controls.
  • This reduction is observed irrespective of a history of optic neuritis.
  • RNFL thickness did not correlate with disability or disease duration in this cohort.