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Related Concept Videos

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Related Experiment Video

Updated: May 14, 2026

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature
08:46

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature

Published on: October 30, 2014

Improved slice-selective adiabatic excitation.

Priti Balchandani1, Gary Glover, John Pauly

  • 1Department of Radiology, Stanford University, Stanford, California, USA.

Magnetic Resonance in Medicine
|February 13, 2013
PubMed
Summary
This summary is machine-generated.

A new Slice-selective Tunable-flip AdiaBatic Low peak-power Excitation (STABLE-2) pulse offers improved performance for MRI, providing shorter durations and better off-resonance immunity. This advanced pulse also enables B1-insensitive fat suppression for enhanced imaging capabilities.

Keywords:
B1-insensitiveRF excitationSTABLEShinnar Le-Rouxadiabaticfat suppressionoff-resonanceslice-selective

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Radiofrequency Pulse Design

Background:

  • Slice-selective excitation is crucial for Magnetic Resonance Imaging (MRI).
  • Existing adiabatic pulses face limitations in duration, off-resonance performance, and B1 field inhomogeneity.
  • Improving pulse design enhances MRI applicability and image quality.

Purpose of the Study:

  • To design an improved Slice-selective Tunable-flip AdiaBatic Low peak-power Excitation (STABLE) pulse, termed STABLE-2.
  • To enhance STABLE-2 with shorter duration and increased off-resonance immunity for broader applications and higher field strengths.
  • To develop a STABLE-2 variant for B1-insensitive, fat-suppressed excitation.

Main Methods:

  • The adiabatic Slice-by-Slice (SLR) algorithm was employed to generate STABLE-2.
  • Pulse parameters were optimized for a uniform spectral envelope and a spectral null for fat suppression.
  • The STABLE-2 pulse was tested in vivo on human brain and knee imaging at 3 T and 7 T.

Main Results:

  • STABLE-2 demonstrated robust and uniform slice-selective excitation across varying B1 values in human brain imaging at 3 T and 7 T.
  • Phantom and in vivo knee imaging confirmed STABLE-2's efficacy for fat suppression at 3 T.
  • The 9.8-ms STABLE-2 pulse achieved slice selectivity over 120 Hz, surpassing the original 21-ms STABLE pulse's 80 Hz limit.

Conclusions:

  • STABLE-2 provides superior B1-insensitive slice-selective excitation with enhanced off-resonance immunity and shorter duration compared to the original STABLE pulse.
  • The developed STABLE-2 variant successfully achieves B1-insensitive, fat-suppressed excitation.
  • These advancements expand the utility of adiabatic pulses in MRI, particularly at higher field strengths.