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Updated: May 14, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

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Published on: July 16, 2014

Primary progressive aphasia with parkinsonism.

Karen M Doherty¹, Jonathan D Rohrer, Andrew J Lees

¹Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK.

Movement Disorders : Official Journal of the Movement Disorder Society

|February 13, 2013

Summary

This case study details a 65-year-old man with progressive aphasia and parkinsonism, highlighting the clinical course and neuroimaging findings of a rare neurodegenerative disease.

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Area of Science:

Neurology
Neuroscience
Clinical Medicine

Background:

This report describes a rare neurodegenerative disorder presenting with initial word-finding difficulties and gait disturbance.
The patient exhibited progressive nonfluent speech, anomia, and impaired repetition, alongside asymmetrical parkinsonian features.

Observation:

The patient's cognitive functions initially remained intact, but later showed deterioration in comprehension.
Motor speech disorder and parkinsonism worsened over 12 years, with limited levodopa response.

Findings:

Serial brain MRI demonstrated progressive asymmetric perisylvian atrophy.
The case illustrates a complex interplay between language and motor deficits in neurodegeneration.

Implications:

This case underscores the importance of recognizing atypical presentations of neurodegenerative diseases.
Understanding such cases aids in differential diagnosis and potential therapeutic strategies for related conditions.