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Lewy body pathology in a patient with a homozygous parkin deletion

Saori Miyakawa1, Mieko Ogino, Sayaka Funabe

  • 1Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan. saomiya@med.kitasato-u.ac.jp

Movement Disorders : Official Journal of the Movement Disorder Society
|February 13, 2013
PubMed
Abstract

Insights

This study details neuropathologic findings in a parkin gene mutation patient, revealing the unexpected presence of Lewy bodies, a key Parkinson's disease hallmark.

Area of Science:

  • Neuropathology
  • Genetics
  • Neurodegenerative Diseases

Background:

  • Investigates neuropathologic findings in a patient with homozygous parkin gene deletions (exons 2-4).
  • Parkin mutations are typically associated with the absence of Lewy bodies.

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