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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: May 14, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Preterm neonates display altered plasmacytoid dendritic cell function and morphology.

S S Schüller1, K Sadeghi, Lukas Wisgrill

  • 1Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria.

Journal of Leukocyte Biology
|February 13, 2013
PubMed
Summary
This summary is machine-generated.

Preterm newborns have decreased functionality of plasmacytoid dendritic cells (pDCs), impacting their ability to produce IFN-α. This reduced immune response may increase susceptibility to viral infections in premature infants.

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Last Updated: May 14, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
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Published on: March 17, 2014

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
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Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

  • Immunology
  • Neonatal Research
  • Infectious Diseases

Background:

  • Bacterial and viral infections pose significant health risks to premature newborns.
  • Plasmacytoid dendritic cells (pDCs) are crucial for antiviral immunity through Interferon-alpha (IFN-α) production upon Toll-like receptor 9 (TLR9) activation.

Purpose of the Study:

  • To compare the frequency, phenotype, morphology, and function of pDCs in preterm newborns, term newborns, and adults.
  • To investigate the impact of prematurity on pDC's capacity to produce IFN-α.

Main Methods:

  • Analysis of pDC frequency and phenotype in peripheral blood.
  • Assessment of IFN-α production capacity following TLR9 stimulation.
  • Electron microscopy to evaluate pDC morphology.

Main Results:

  • Preterm neonates showed similar pDC numbers but decreased expression of BDCA-4 and reduced IFN-α production compared to term infants and adults.
  • Electron microscopy revealed an immature morphology in pDCs from preterm newborns.
  • TLR9 and BDCA-2 expression levels were comparable across all age groups.

Conclusions:

  • pDCs in preterm newborns exhibit decreased functionality, characterized by reduced IFN-α production and immature morphology.
  • This impaired pDC function likely contributes to increased susceptibility to viral infections in premature infants.