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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Using aptamers for cancer biomarker discovery.

Yun Min Chang¹, Michael J Donovan, Weihong Tan

¹Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

Journal of Nucleic Acids

|February 13, 2013

Summary

Aptamers, which are synthetic DNA or RNA molecules, can be used to discover cancer biomarkers. These biomarkers are crucial for cancer diagnosis and developing new therapeutics.

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Area of Science:

Biochemistry
Molecular Biology
Biotechnology

Background:

Aptamers are single-stranded DNA or RNA oligonucleotides with high affinity and specificity for target molecules.
Aptamer selection is achieved through Systematic Evolution of Ligands by Exponential Enrichment (SELEX) and cell-SELEX.
Aptamers offer an alternative to antibodies in molecular recognition applications.

Purpose of the Study:

To explore the utility of aptamers in biomarker discovery for cancer.
To highlight the role of aptamers in advancing cancer diagnosis and therapeutics.

Main Methods:

Description of aptamer selection techniques (SELEX and cell-SELEX).
Discussion of aptamer integration with advanced technologies like nanotechnology and microfluidics.
Review of aptamer applications in biomarker identification.

Main Results:

Aptamers demonstrate high specificity and affinity for various targets, including cancer biomarkers.
Integration of aptamers with other technologies enhances their potential in clinical applications.
Aptamers show promise for novel cancer biomarker discovery.

Conclusions:

Aptamers are valuable tools for identifying cancer biomarkers.
Aptamer-based approaches can significantly contribute to cancer diagnosis and therapeutic strategies.
Further research into aptamer applications will advance precision oncology.