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Updated: May 14, 2026

Application of Laparoscopic Ultrasonography in Primary Choledochal Suture during Combined Two-lens Surgery
Published on: March 28, 2025
Chronically symptomatic patients with undetectable gall bladder on ultrasonography could benefit from early
Stephen D Adams1, Simon C Blackburn, Victoria A Adewole
1Department of Paediatric Surgery, Royal Alexandra Children's Hospital, Eastern Road, Brighton BN2 5BE, UK.
Insights
Gallbladder non-visualization on ultrasound may indicate chronic acalculous cholecystitis. Consider cholecystectomy for persistent biliary dyspepsia when the gallbladder is not seen on imaging.
Area of Science:
- Gastroenterology
- Diagnostic Imaging
Background:
- Cholelithiasis is common in patients undergoing cholecystectomy, with gallbladders typically visible on ultrasonography.
- Diagnosing symptomatic biliary dyspepsia in children is challenging when gallstones are absent and the gallbladder is not visualized on repeated imaging.
Purpose of the Study:
- To investigate the significance of gallbladder non-visualization in pediatric patients with symptomatic biliary dyspepsia.
- To determine if non-visualized gallbladders on ultrasonography correlate with chronic acalculous cholecystitis.
Main Methods:
- Retrospective review of 54 cholecystectomy cases.
- Identification of cases with recurrent right upper quadrant pain and undetectable gallbladders on repeat ultrasonography.
- Histological examination of excised gallbladders.
Main Results:
- Three cases presented with recurrent pain and non-visualized gallbladders on ultrasonography.
- All three patients underwent successful cholecystectomy.
- Histology revealed markedly fibrotic and thickened gallbladders in all identified cases.
Conclusions:
- Non-visualization of the gallbladder on repeated ultrasonography may be a key feature of chronic acalculous cholecystitis.
- Cholecystectomy should be considered for chronic biliary dyspepsia when ultrasonography fails to visualize the gallbladder.
Abstract:
90 percent of symptomatic patients undergoing cholecystectomy have cholelithiasis with 10% categorized as asymptomatic cholecystitis. In both instances, the gallbladder is evident on ultrasonography. In children with symptomatic biliary dyspepsia, the decision to proceed to cholecystectomy is made difficult if choleliths are not seen on ultrasonography. This decision is made even more difficult if the gallbladder itself is not seen on repeated imaging. In a cohort of 54 cholecystectomies, 3 cases, with recurrent right upper quadrant pain and undetectable gallbladders on repeat ultrasonography, were identified. After prolonged observation all underwent successful cholecystectomy. Histology demonstrated a markedly fibrotic and thickened gallbladder in all. Given this experience, we suggest that nonvisibility of the gallbladder, in fact, maybe be a feature of a chronic acalculous cholecystitis. We advise consideration of cholecystectomy for chronic biliary dyspepsia where repeat ultrasonography fails to demonstrate a gallbladder.
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