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Drug adsorption to charcoals and anionic binding resins
A H al-Shareef1, D C Buss, P A Routledge
1Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Llandough Hospital, Penarth, S. Glamorgan, UK.
Human & Experimental Toxicology
|March 1, 1990
Summary
This study compared drug binding to charcoal and resins. Charcoals adsorbed metoclopramide and antipyrine more than warfarin or paracetamol, while resins showed varied drug-specific capacities.
Area of Science:
- Pharmacology
- Materials Science
Background:
- Drug adsorption by binding agents is crucial for overdose management and drug interactions.
- Charcoal and anionic exchange resins are commonly used adsorbents.
Purpose of the Study:
- To investigate the in-vitro binding of four drugs to two charcoal preparations and two anionic binding resins.
- To compare the adsorption capacities and specificities of different binding agents for various drugs.
Main Methods:
- In-vitro adsorption studies were conducted at 37°C and pH 7.4.
- Four drugs with diverse physicochemical properties were tested against Carbomix, Medicoal (charcoals), Cholestyramine, and Colestipol (resins).
Main Results:
- Charcoals (Carbomix, Medicoal) showed higher adsorption for metoclopramide and antipyrine compared to warfarin and paracetamol.
- Cholestyramine exhibited greater capacity for warfarin but lower for paracetamol and metoclopramide than charcoals.
- Colestipol demonstrated significant binding of metoclopramide and less for antipyrine compared to other agents.
Conclusions:
- Adsorption profiles varied significantly between charcoal and resin binding agents for the tested drugs.
- No consistent correlation was found between drug physicochemical properties (pKa, molecular weight) and adsorbent capacity.