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[Treatment of chronic viral hepatitis: achievements and prospects]

E V Golovanova

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |February 14, 2013
    PubMed

    Insights

    This review examines antiviral therapy for chronic viral hepatitis B and C, including treatment strategies for inadequate responses and special considerations for liver cirrhosis patients.

    Area of Science:

    • Hepatology
    • Virology
    • Internal Medicine

    Context:

    • Chronic viral hepatitis (CVH), specifically hepatitis B (HBV) and C (HCV), remains a significant global health concern.
    • Current treatment guidelines and emerging therapies for CVH require continuous evaluation and updates.
    • Understanding treatment responses and resistance patterns is crucial for optimizing patient outcomes.

    Purpose:

    • To provide a comprehensive overview of the current state of chronic viral hepatitis B and C.
    • To analyze the effectiveness of antiviral therapy (AVT) for chronic HCV infection and explore treatment tactics for patients with inadequate responses.
    • To discuss the latest advancements and future perspectives in the management of chronic hepatitis C and B, including comparative effectiveness of interferon (IFN) and nucleoside analogs (AN) for CH B, and treatment in liver cirrhosis (LC).

    Summary:

    • The review analyzes the efficacy of current antiviral therapy (AVT) regimens for chronic hepatitis C (HCV) and examines treatment strategies for patients who do not respond adequately.
    • It evaluates the effectiveness of AVT for chronic hepatitis B (HBV), comparing interferon (IFN) and nucleoside analogs (AN).
    • Special emphasis is placed on managing chronic viral infections in patients with liver cirrhosis (LC) and highlights upcoming developments in CH C treatment.

    Impact:

    • This review offers critical insights into optimizing AVT for chronic viral hepatitis, potentially improving patient management and outcomes.
    • It informs clinicians about the latest treatment tactics and future directions in managing CH C and CH B, especially in complex cases like liver cirrhosis.
    • The findings contribute to the evidence base for developing more effective and personalized treatment strategies for viral hepatitis.

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