The evolution of oral anticoagulant therapy

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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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Published on: October 12, 2012

Christopher Dittus1, Jack Ansell

  • 1Department of Medicine, Lenox Hill Hospital, 100 East 77th Street, New York, NY 10075, USA. cdittus@nshs.edu

Primary Care
|February 14, 2013
PubMed

Insights

New oral anticoagulants offer greater patient and physician choice beyond warfarin. Factors like dosing and reversal guide selection for personalized anticoagulant therapy.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Historically, warfarin was the sole oral anticoagulant option.
  • Limited choices impacted personalized patient treatment strategies.

Purpose of the Study:

  • To compare new oral anticoagulants with warfarin.
  • To highlight factors influencing anticoagulant selection.

Main Methods:

  • Review of pharmacokinetic and pharmacodynamic properties.
  • Analysis of clinical data on dosing, half-life, elimination, monitoring, and reversal.

Main Results:

  • New oral direct thrombin and factor Xa inhibitors provide diverse options.
  • Variations in drug profiles allow for tailored therapeutic decisions.

Conclusions:

  • New oral anticoagulants complement warfarin, each serving specific clinical niches.
  • Bedside clinical judgment is crucial for selecting the optimal anticoagulant for individual patients.

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