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Related Experiment Videos

The anorectic effects of CRH and restraint stress decrease with repeated exposures.

D D Krahn1, B A Gosnell, M J Majchrzak

  • 1University of Michigan Medical Center, Department of Psychiatry, Ann Arbor 48109-0116.

Biological Psychiatry
|May 15, 1990
PubMed
Summary
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Rats developed tolerance to the appetite-suppressing effects of repeated corticotropin-releasing hormone (CRH) injections. This suggests potential mechanisms for anorexia nervosa and depression.

Area of Science:

  • Neuroendocrinology
  • Behavioral Neuroscience

Background:

  • Corticotropin-releasing hormone (CRH) and stress induce acute anorexia in rats.
  • Chronic effects of CRH and stress on food intake are less understood.
  • Eating and affective disorders may involve chronic CRH and stress pathways.

Purpose of the Study:

  • To investigate the effects of repeated intracerebroventricular (icv) CRH administration on food intake and body weight in rats.
  • To determine if tolerance develops to the anorectic effects of CRH with repeated central administration.

Main Methods:

  • Rats received daily icv injections of CRH at two different dosages and schedules.
  • Food intake and body weight were monitored throughout the experiments.

Main Results:

Related Experiment Videos

  • The anorectic effect of CRH diminished with repeated injections, indicating developing tolerance.
  • Significant reduction in weight gain was observed only in the high-dose CRH group.
  • Tolerance to CRH-induced anorexia may occur following repeated central administration.

Conclusions:

  • Repeated central CRH administration leads to tolerance in anorectic effects.
  • Findings suggest CRH tolerance may be relevant to the pathophysiology of human eating and mood disorders.
  • Further research into CRH pathways is warranted for understanding anorexia nervosa and depression.