Related Experiment Video

Updated: May 14, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Increased peritoneal dialysis exit site infections using topical antiseptic polyhexamethylene biguanide compared to

Andrew Findlay1, Charelle Serrano, Sally Punzalan

  • 1Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, United Kingdom.

Antimicrobial Agents and Chemotherapy
|February 14, 2013
PubMed

Insights

Polyhexamethylene biguanide (PHMB) did not effectively prevent peritoneal catheter exit site infections (ESIs) compared to mupirocin. The study found PHMB led to a higher ESI rate, resulting in trial discontinuation.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Antimicrobial Stewardship

Background:

  • Peritoneal catheter exit site infections (ESIs) are a significant complication in patients undergoing peritoneal dialysis.
  • Prophylactic mupirocin reduces ESI risk but raises concerns about antibiotic resistance.
  • Novel antimicrobial agents are needed to prevent ESIs while mitigating resistance.

Purpose of the Study:

  • To compare the safety and efficacy of polyhexamethylene biguanide (PHMB) versus mupirocin for preventing ESIs in peritoneal dialysis patients.
  • To assess the exit site infection rate in patients randomized to PHMB or mupirocin prophylaxis.

Main Methods:

  • An open-label, randomized study was conducted.
  • 106 patients were randomized into two groups: 53 receiving PHMB and 53 receiving mupirocin.
  • Patients were followed for a mean of 12.68 months for safety analysis, focusing on ESI rates.

Main Results:

  • The PHMB group experienced a significantly higher rate of exit site infections compared to the mupirocin group.
  • The odds ratio for ESI in the PHMB group was 0.26 (95% CI, 0.09 to 0.80), indicating a protective effect of mupirocin.
  • These interim safety findings led to the discontinuation of the trial.

Conclusions:

  • Polyhexamethylene biguanide (PHMB) is less effective than mupirocin in preventing peritoneal catheter exit site infections.
  • Mupirocin remains a preferred prophylactic agent for peritoneal catheter exit sites despite resistance concerns.
  • Further research into alternative prophylactic strategies is warranted.

More Related Videos

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection05:32

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

Related Concept Videos

Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...