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Updated: May 14, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity
Stephenie Alvarado1, Bracken F Roberts, Amy E Wright
1Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Abstract:
A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC(50)).
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