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Pharmacokinetic aspects of the sublingual administration of vincamine
J M Aiache1, M C Delatte, P P Leblanc
1Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
Biopharmaceutics & Drug Disposition
|May 1, 1990
Abstract:
The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed.