Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of COVID-19 on absolute neutrophil counts in patients taking clozapine.

Therapeutic advances in psychopharmacology·2020
Same author

Safety of psychotropic medications in people with COVID-19: evidence review and practical recommendations.

BMC medicine·2020
Same author

Role of <i>Helicobacters</i> in Neuropsychiatric Disease: A Systematic Review in Idiopathic Parkinsonism.

Journal of clinical medicine·2020
Same author

Constructing Approaches to Entrustable Professional Activity Development that Deliver Valid Descriptions of Professional Practice.

Teaching and learning in medicine·2020
Same author

Emerging and experimental treatments for COVID-19 and drug interactions with psychotropic agents.

Therapeutic advances in psychopharmacology·2020
Same author

Bio-inspired protective structures for marine applications.

Bioinspiration & biomimetics·2020
Same journal

Child and Adolescent Psychiatry in the Far East: Findings from Multi-National Surveys.

Current psychiatry reports·2026
Same journal

Involuntary Celibacy in the Digital Age: a Critical Narrative Review of the Incel Phenomenon, Mental Health Burden, Ideological Pathways, and Public Health Implications.

Current psychiatry reports·2026
Same journal

Is Technology Remaking Therapy: The Screen and the Self: Telepsychiatry, AI Therapy, and the Defense Against Intimacy.

Current psychiatry reports·2026
Same journal

Bridging Gaps in Perinatal Mental Health: A Review of Peer and Non-specialist Supports for Racially, Ethnically and Culturally Diverse Communities in the U.S.

Current psychiatry reports·2026
Same journal

Psychosocial Preparedness for Disasters: A Scoping Review of International Models and Public Health Priorities.

Current psychiatry reports·2026
Same journal

Artificial Intelligence in Child and Adolescent Psychiatry: A Narrative Review of Recent Clinical Applications and Ethical Considerations.

Current psychiatry reports·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Behavioral interventions for antipsychotic induced appetite changes.

Ursula Werneke1, David Taylor, Thomas A B Sanders

  • 1Department of Clinical Sciences, Division of Psychiatry, Umeå University, 90185 Umeå, Sweden. uwerneke@gmail.com

Current Psychiatry Reports
|February 14, 2013
PubMed
Summary
This summary is machine-generated.

Antipsychotic medications often cause weight gain by increasing appetite. New strategies targeting appetite regulation, like specific diets or metformin, may improve weight management for patients on these drugs.

More Related Videos

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Related Experiment Videos

Last Updated: May 14, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Area of Science:

  • Pharmacology
  • Neuroendocrinology
  • Behavioral Science

Background:

  • Weight gain is a common and challenging side effect of first and second-generation antipsychotic medications.
  • Antipsychotic-induced weight gain is linked to increased appetite, making behavioral interventions less effective.
  • Current weight management options for patients on antipsychotics are limited.

Purpose of the Study:

  • To explore novel interventions for managing antipsychotic-induced weight gain.
  • To identify strategies that specifically target the neuroendocrine mechanisms regulating appetite.
  • To improve the efficacy of behavioral weight management programs in this patient population.

Main Methods:

  • Review of potential interventions targeting appetite regulation.
  • Consideration of dietary approaches that do not increase appetite.
  • Evaluation of strategies to manage anticholinergic side effects like thirst.
  • Assessment of the role of discouraging cannabis use.
  • Exploration of metformin as an adjunct therapy.

Main Results:

  • Novel strategies may enhance weight management efficacy.
  • Dietary modifications, managing thirst, and discouraging cannabis use are potential avenues.
  • Metformin may be a beneficial addition to behavioral interventions.

Conclusions:

  • Systematic exploration of novel weight management options is timely.
  • Targeting specific neuroendocrine factors offers a promising approach.
  • Improving treatment options for antipsychotic-induced weight gain is crucial for patient care.