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Implanted bisphosphonates in bone cement affect bone markers in rat serum
Tomasz Mazurkiewicz1, Lukasz Matuszewski, Anna Matuszewska
1Orthopedic and Traumatology Department, Medical University of Lublin, Lublin, Poland.
International Orthopaedics
|February 14, 2013
Summary
Bisphosphonate-enriched bone cement increased osteoprotegerin ligand (OPG) and decreased receptor activator of nuclear factor kappa-B ligand (RANKL) in rats. This suggests bisphosphonates in bone cement effectively reduce bone resorption.
Area of Science:
- Orthopedics
- Biomaterials Science
- Pharmacology
Background:
- Bisphosphonates (BPs) are antiresorptive drugs crucial for managing bone resorption diseases.
- Their efficacy stems from bone affinity and specific molecular mechanisms.
- BPs are vital in treating conditions like bone metastasis and Paget's disease.
Purpose of the Study:
- To investigate the effect of bisphosphonate (Pamifos®) incorporated into bone cement on bone turnover.
- To analyze serum cytokine level changes in rats following surgical implantation of BP-enriched cement.
Main Methods:
- The study involved 40 adult male Wistar rats divided into control and experimental groups.
- Experimental groups received bone implants with BP-enriched cement.
- Control groups received implants with clean cement (without BPs).
Main Results:
- Rats with BP-enriched cement showed higher tumor necrosis factor alpha (TNF-α) levels at three weeks post-surgery.
- TNF-α levels decreased in the BP group and increased in the control group by six weeks.
- Osteoprotegerin ligand (OPG) concentrations were elevated in rats with BP implants.
- Receptor activator of nuclear factor kappa-B ligand (RANKL) levels were high in rats with cement lacking BPs.
Conclusions:
- Bisphosphonate (Pamifos®) in bone cement influences bone turnover by increasing OPG and decreasing RANKL.
- These effects suggest BPs in bone cement contribute to reduced bone resorption.
- The use of BP-enriched bone cement implants is supported by these findings.
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