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[Aromatases inhibitors for breast cancer in menopausal patients]

Mehdi Afrit1, Soumaya Laabidi, Khedija Meddeb

  • 1Service de carcinologie médicale, Hôpital Abderrahman Mami, Ariana, Tunis, Tunisie.

La Tunisie Medicale
|February 14, 2013
PubMed
Abstract

Insights

Aromatase inhibitors (AI) are superior to tamoxifen for early breast cancer adjuvant treatment in postmenopausal women, reducing mortality and recurrence risks. AI are now standard care, improving disease-free survival.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Context:

  • Early breast cancer (BC) management in postmenopausal women.
  • Evaluating adjuvant treatments to improve patient outcomes.
  • Comparing efficacy and safety of Aromatase Inhibitors (AI) versus tamoxifen.

Purpose:

  • To review and analyze data from major international randomized trials on adjuvant Aromatase Inhibitors (AI) for early breast cancer.
  • To assess the impact of AI on current clinical practice for breast cancer management.

Summary:

  • A literature review of 30 publications on AI, including trials like ATAC, BIG, MA17, and IES, involving anastrozole, letrozole, and exemestane.
  • AI demonstrated superiority over tamoxifen in upfront and switch settings, reducing mortality rates and contralateral breast cancer risk.
  • AI offer a better tolerance profile than tamoxifen and significantly improve disease-free survival.

Impact:

  • AI have revolutionized adjuvant breast cancer treatment, leading to their systematic use in postmenopausal patients.
  • Current adjuvant hormonotherapy for postmenopausal women relies on AI due to proven benefits.
  • AI excel in reducing distant and contralateral risks and improving disease-free survival, though overall survival benefits are less pronounced.

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