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Updated: May 14, 2026

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
08:01

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal

Published on: May 30, 2012

Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3

Laralynne M Przybyla1, Thorold W Theunissen, Rudolf Jaenisch

  • 1Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Stem Cells (Dayton, Ohio)
|February 14, 2013
PubMed
Summary

Matrix metalloproteinases (MMPs) remodel the extracellular matrix, aiding embryonic stem cell (ESC) self-renewal. MMP1 addition supports leukemia inhibitory factor-independent mouse ESC self-renewal by exposing trapped growth factors.

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