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Antiplaque activity of some antimicrobial agents using a simple in vitro method
1School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Caries Research
|January 1, 1990
Summary
Certain antimicrobial compounds effectively reduced Streptococcus sobrinus plaque in vitro. This antiplaque activity suggests that potent bactericidal properties are not always required for plaque reduction.
Area of Science:
- Microbiology
- Dental Research
- Antimicrobial Agents
Background:
- Dental plaque, primarily composed of Streptococcus sobrinus, is a major contributor to oral health issues.
- Developing effective antiplaque agents is crucial for preventing dental caries and periodontal diseases.
- Understanding the mechanisms of antiplaque activity can lead to more targeted therapeutic strategies.
Purpose of the Study:
- To evaluate the antiplaque efficacy of various antimicrobial compounds against Streptococcus sobrinus in vitro.
- To investigate the relationship between bactericidal activity and antiplaque effects.
Main Methods:
- A simple in vitro method was employed to assess antiplaque activity.
- The weight of Streptococcus sobrinus plaque formed on a glass surface was measured.
- Several antimicrobial compounds, including chlorhexidine, cetylpyridinium chloride, n-tetradecylamine, and specific polymethylenediamine derivatives, were tested.
Main Results:
- Chlorhexidine, cetylpyridinium chloride, and n-tetradecylamine demonstrated significant reduction in Streptococcus sobrinus plaque weight.
- N-palmityl and palmitoyl derivatives of polymethylenediamines also exhibited notable antiplaque activity.
- A correlation between high bactericidal activity and antiplaque effect was not consistently observed.
Conclusions:
- Several tested antimicrobial compounds possess in vitro antiplaque activity against Streptococcus sobrinus.
- Antiplaque efficacy may be independent of high bactericidal potency.
- These findings suggest alternative mechanisms for plaque inhibition that warrant further investigation.