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[Cancer risk among shift workers: a review]
M Puligheddu1, S Conti, M Campagna
1Sezione di Neurologia, Università di Cagliari.
Introduction:
According to IARC, shift work resulting in disruption of circadian rhythm is a probable human carcinogen (Group 2A).
Methods:
We examined the scientific literature on the carcinogenic risk among shift workers for risk assessment purposes.
Results:
Clock genes polymorphisms might contribute with suppression of melatonin synthesis, immuno-suppression from sleep deprivation, individual habits associated with shift work, and low vitamin D levels, in increasing risk of breast cancer, prostate cancer and lymphoma among shift workers.
Conclusion:
Although the epidemiological evidence seems scanty, the hypothesis that shift work-related sleep deprivation would contribute to increasing cancer risk seems based on solid ground.
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