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Updated: May 14, 2026

The Intra-Aortic Balloon Pump
Published on: February 5, 2021
Supporting the failing myocardium: is intra-aortic balloon pump enough? The IABP-SHOCK II trial
Smita I Negi1, Biswajit Kar, Igor Gregoric
1Center for Advanced Heart Failure and Heart Transplantation, University of Texas Health Science Center, Houston, TX, USA.
Insights
Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) has high mortality. A recent trial found intra-aortic balloon pumps do not improve 30-day outcomes for CS in AMI, challenging current management strategies.
Area of Science:
- Cardiology
- Critical Care Medicine
- Interventional Cardiology
Background:
- Cardiogenic shock (CS) in acute myocardial infarction (AMI) remains a significant cause of mortality.
- Intra-aortic balloon pumps (IABP) have been a standard treatment for CS complicating AMI.
- Recent evidence questions the efficacy of IABP in improving patient outcomes.
Discussion:
- This review critically examines the findings of Thiele et al.'s randomized controlled trial on IABP use in CS complicating AMI.
- The trial demonstrated no significant improvement in 30-day mortality or other key outcomes with IABP use.
- The results necessitate a re-evaluation of current clinical guidelines and treatment protocols.
Key Insights:
- The use of intra-aortic balloon pumps in cardiogenic shock complicating acute myocardial infarction does not improve 30-day outcomes.
- This finding challenges the long-standing role of IABP as a primary intervention in this critical condition.
- Clinical decision-making for CS in AMI must adapt to this new evidence.
Outlook:
- Future research should focus on alternative or adjunctive therapies for CS in AMI.
- Exploring novel mechanical circulatory support devices is crucial.
- Revised clinical practice guidelines are anticipated based on these trial results.
Abstract:
Cardiogenic shock (CS) in acute myocardial infarction (AMI) is associated with high mortality. Ventricular support devices such as intra-aortic balloon pumps have been used in the acute management of this condition. However, a recent randomized controlled trial conducted by Thiele et al. showed that the use of an intra-aortic balloon pump in CS in AMI does not improve 30-day outcomes in these patients. In the following review, the authors discuss the salient features of the article, how the results of this trial are likely to change the management strategies in CS in the setting of AMI and the future directions.
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