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Updated: May 14, 2026
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Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
Published on: August 2, 2024
Patient selection for cardiac transplant in 2012
Mona Parikh Kinkhabwala1, Donna Mancini
1Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Expert Review of Cardiovascular Therapy
|February 15, 2013
Summary
Selecting the right time for heart transplantation is crucial for advanced heart failure patients. Evolving strategies balance transplant with mechanical support, optimizing outcomes and resource use.
Area of Science:
- Cardiology
- Transplantation Medicine
- Advanced Heart Failure Management
Background:
- Heart transplantation is the primary treatment for advanced heart failure unresponsive to medical therapy.
- Improved outcomes in heart transplantation necessitate refined patient selection due to limited donor organs.
- Advancements in mechanical circulatory support (MCS) impact decisions for bridge-to-transplant or destination therapy.
Purpose of the Study:
- To review optimal timing for heart transplantation.
- To analyze risk stratification models for patient selection in advanced heart failure.
- To discuss evolving contraindications and selection controversies in cardiac transplantation.
Main Methods:
- Literature review focusing on heart transplantation guidelines and outcomes.
- Analysis of risk stratification tools for heart transplant candidates.
- Examination of changing contraindications based on clinical experience and evolving therapies.
Main Results:
- Patient selection and risk stratification are critical for successful heart transplantation.
- The choice between heart transplant, mechanical support, or combined strategies is becoming more complex.
- Previously absolute contraindications are now relative, reflecting increased clinical experience and improved supportive care.
Conclusions:
- Optimal timing and careful patient selection are paramount for heart transplantation success.
- Evolving mechanical circulatory support technologies necessitate dynamic selection strategies.
- Continuous reassessment of contraindications is vital as cardiac transplantation advances.
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