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Preadolescent indomethacin-responsive headaches without autonomic symptoms

Kenneth Alexis Myers1, Kim A Smyth

  • 1Pediatrics, Division of Neurology, University of Calgary, Calgary, AB, Canada.

Headache
|February 15, 2013
PubMed

Insights

Preadolescent patients with severe, sudden headaches responded well to indomethacin. This suggests a potential new syndrome of indomethacin-responsive headache in children, even without typical autonomic symptoms.

Area of Science:

  • Pediatric Neurology
  • Pharmacology

Background:

  • Preadolescent indomethacin-responsive headache is a rare condition with limited research.
  • Understanding this entity is crucial for accurate diagnosis and treatment in young patients.

Observation:

  • Two preadolescent children presented with frequent, severe, sudden-onset headaches.
  • Headaches were paroxysmal, lasting seconds to minutes, with no associated autonomic or migrainous features.
  • Extensive work-up excluded secondary causes for the debilitating headaches.

Findings:

  • Both patients experienced dramatic clinical improvement with indomethacin treatment.
  • This response suggests a specific headache syndrome responsive to indomethacin.

Implications:

  • A distinct pediatric syndrome of indomethacin-responsive headache, potentially without autonomic symptoms, may exist.
  • Further research is needed to establish optimal dosage and treatment duration for pediatric indomethacin-responsive headache.
  • Indomethacin should be considered for severe paroxysmal headaches in children after ruling out secondary causes.
Abstract

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