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Hyperlipidaemia increases albuminuria in hypertensive and normotensive rats
M E Cooper1, D A Vranes, S Panagiotopoulos
1Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia.
Clinical and Experimental Pharmacology & Physiology
|March 1, 1990
Abstract:
1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total-cholesterol and a decrease in HDL-cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol-fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.