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Updated: May 14, 2026

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Published on: September 30, 2016
Everolimus in colorectal cancer
Ivy Altomare1, Herbert Hurwitz
1Duke University Medical Center, Division of Medical Oncology, 3100 Tower Blvd Ste 600, Durham, NC 27707, USA. Ivy.altomare@duke.edu
Everolimus shows limited effectiveness as a single treatment for advanced colorectal cancer, with toxicity concerns. Further research into combination therapies targeting the PI3K/mTOR pathway may still hold promise for colorectal malignancies.
Area of Science:
- Oncology
- Pharmacology
Background:
- Preclinical studies supported mammalian target of rapamycin (mTOR) inhibitors for various cancers, including colorectal cancer.
- The PI3K/mTOR pathway is crucial in cancer biology, suggesting potential therapeutic targets.
Purpose of the Study:
- To review the clinical efficacy of everolimus in colorectal cancer.
- To evaluate combination regimens involving everolimus in colorectal cancer treatment.
Main Methods:
- Comprehensive review of published and abstract clinical trials of everolimus in colorectal cancer.
- Analysis of Phase I and Phase II trials for single-agent and combination therapies.
Main Results:
- Single-agent everolimus demonstrated limited clinical activity in advanced metastatic colorectal carcinoma.
- While tolerable, everolimus monotherapy did not yield significant objective tumor responses or prolonged stable disease.
- Combination regimens with chemotherapy and other targeted inhibitors showed mixed results.
Conclusions:
- Everolimus exhibits restricted clinical activity for advanced colorectal cancer, with increased toxicity.
- Despite limited success, targeting the PI3K/mTOR pathway with novel drug combinations warrants further investigation.
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