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Persistent splenic visualization on technetium-99m DISIDA hepatobiliary studies.

J Balseiro1, M J Fratkin, J I Hirsch

  • 1Veterans Administration Medical Center, Richmond, Virginia 23249.

Clinical Nuclear Medicine
|April 1, 1990
PubMed
Summary
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Persistent splenic visualization during technetium-99m DISIDA imaging is more common than previously thought. This finding may be linked to elevated levels of reduced, hydrolyzed technetium (colloid) in the radiopharmaceutical.

Area of Science:

  • Nuclear Medicine
  • Diagnostic Imaging
  • Hepatobiliary Imaging

Background:

  • Technetium-99m DISIDA (diisopropyl iminodiacetic acid) is a standard radiotracer for evaluating biliary system disorders.
  • Current understanding suggests splenic visualization on DISIDA scans is limited to the blood pool phase.

Purpose of the Study:

  • To investigate the actual incidence of persistent splenic visualization during technetium-99m DISIDA imaging.
  • To explore potential correlations between splenic visualization and patient demographics or diagnoses.

Main Methods:

  • Retrospective review of 245 technetium-99m DISIDA examinations from two institutions.
  • Quality control of radiochemical purity using sephadex gel column chromatography.
  • Analysis of patient age, sex, and final diagnosis in relation to splenic visualization.

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Main Results:

  • Persistent splenic visualization was observed in 1.0% of studies at Institution #1 and 7.3% at Institution #2.
  • No significant correlation was found between persistent splenic visualization and patient age, sex, or final diagnosis.
  • The incidence of persistent splenic visualization was higher than generally acknowledged.

Conclusions:

  • Persistent splenic visualization on technetium-99m DISIDA scans occurs more frequently than previously recognized.
  • Elevated concentrations of reduced, hydrolyzed technetium (colloid) in DISIDA preparations are a potential cause for this phenomenon.
  • Further investigation into the implications of persistent splenic visualization is warranted.