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Updated: May 14, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Do we still need chemotherapy for AIDS-associated Kaposi's sarcoma?
Alessia Dalla Pria1, Katy Hayward, Mark Bower
1National Centre for HIV Malignancy, Chelsea & Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.
Expert Review of Anticancer Therapy
|February 15, 2013
Summary
Combination antiretroviral therapy (cART) has decreased AIDS-associated Kaposi
Area of Science:
- Oncology
- Infectious Diseases
- Immunology
Background:
- Combination antiretroviral therapy (cART) has significantly altered the landscape of Acquired Immunodeficiency Syndrome (AIDS)-associated Kaposi's Sarcoma (AIDS-KS).
- cART has demonstrated efficacy in reducing the incidence and treating early-stage Kaposi's Sarcoma.
Purpose of the Study:
- To evaluate the continued necessity of systemic chemotherapy for AIDS-KS in the era of widespread cART availability.
- To identify specific clinical scenarios where chemotherapy remains indicated for AIDS-KS management.
Main Methods:
- Review of epidemiological data and clinical outcomes of patients with AIDS-KS.
- Analysis of treatment responses in relation to cART effectiveness and disease stage.
Main Results:
- cART has led to a reduced incidence of AIDS-KS and is effective for early-stage disease.
- Chemotherapy remains a critical treatment option for advanced-stage AIDS-KS.
- Patients with progressive KS despite cART, including immune reconstitution inflammatory syndrome (IRIS)-associated KS, require chemotherapy.
Conclusions:
- Systemic chemotherapy retains a vital role in managing specific cases of AIDS-KS.
- Indications for chemotherapy include advanced disease and treatment failure or progression on cART.
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