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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 14, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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The evolution of systemic therapy in sarcoma.

Anastasia Constantinidou1, Seth Pollack, Elizabeth Loggers

  • 1The Royal Marsden Hospital, London, UK.

Expert Review of Anticancer Therapy
|February 15, 2013
PubMed
Summary
This summary is machine-generated.

Recurrent soft tissue sarcomas pose treatment challenges. Novel therapies targeting specific sarcoma subtypes are needed, as some are resistant to conventional chemotherapy.

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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Soft tissue sarcomas frequently recur after surgery, necessitating alternative treatments.
  • Current chemotherapy (doxorubicin, ifosfamide) benefits advanced disease but has limitations.
  • A need exists for more effective and less toxic therapies for these mesenchymal tumors.

Purpose of the Study:

  • To highlight the challenges in managing recurrent and rare soft tissue sarcoma subtypes.
  • To emphasize the shift towards subtype-specific therapies based on tumor biology.
  • To advocate for clinical trial participation for chemotherapy-resistant sarcomas.

Main Methods:

  • Review of current treatment paradigms for soft tissue sarcomas.
  • Discussion of advances in understanding sarcoma subtype biology.
  • Analysis of chemotherapy efficacy across different histological subtypes.

Main Results:

  • Approximately 50% of localized soft tissue sarcomas recur post-resection.
  • Conventional chemotherapy shows limited efficacy in certain subtypes.
  • Novel therapies are being developed for both common and rare sarcoma subtypes.

Conclusions:

  • Management of soft tissue sarcoma, especially rare subtypes, remains challenging.
  • Subtype-specific treatment strategies are increasingly important.
  • Early-phase clinical trials of novel drugs are crucial for patients with resistant disease.