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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Related Experiment Video

Updated: May 14, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Egg hypersensitivity in review.

Sana A Hasan1, Regina D Wells, Carla M Davis

  • 1Department of Internal Medicine and Pediatrics, University of Texas Health Science Center at Houston, Houston, TX, USA.

Allergy and Asthma Proceedings
|February 15, 2013
PubMed
Summary
This summary is machine-generated.

Most children outgrow egg allergy by age 16, with well-cooked eggs often tolerated sooner. Egg-specific IgE levels can predict persistent allergies, guiding management for healthcare providers.

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Area of Science:

  • Allergy and Immunology
  • Pediatric Allergy
  • Food Hypersensitivity

Background:

  • Egg hypersensitivity is a prevalent food allergy, affecting up to 1.7% of the population.
  • Ongoing research continually advances the understanding and management of egg allergy.

Purpose of the Study:

  • To provide healthcare providers with a comprehensive update on the diagnosis and management of egg hypersensitivity.
  • To review current knowledge on allergens, clinical presentation, diagnostic strategies, and treatment options for egg allergy.

Main Methods:

  • Systematic review of recent, clinically applicable literature on egg allergy management.
  • Analysis of diagnostic criteria, including egg-specific IgE levels and food challenges.
  • Evaluation of current treatment modalities and future therapeutic directions.

Main Results:

  • Approximately 70% of children with egg allergy achieve tolerance by age 16.
  • Higher egg-specific IgE levels (>50 kIU(A)/L) may predict persistent allergy.
  • Most egg-allergic patients can receive influenza vaccines, and well-cooked egg ingestion may be tolerated earlier.

Conclusions:

  • Allergists can effectively manage egg allergy using up-to-date information, improving patient quality of life.
  • Double-blind placebo-controlled food challenges remain the gold standard for diagnosis.
  • While oral immunotherapy shows promise, it is not yet standard clinical practice.