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Viral agents associated with acute diarrhea among outpatient children in southeastern China

Yu Chen1, Zhongjie Li, Dongsheng Han

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Center of Clinical Laboratory, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

The Pediatric Infectious Disease Journal
|February 15, 2013
PubMed

Insights

Rotavirus and norovirus are the leading viral causes of acute diarrhea in young children in China. Mixed viral infections are common, with rotavirus playing a significant role.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Public Health

Background:

  • Acute diarrhea is a major global cause of childhood illness and death.
  • Limited data exists on viral causes of acute diarrhea in children in developing nations.

Purpose of the Study:

  • To identify viral agents responsible for acute diarrhea in outpatient children in southeastern China.

Main Methods:

  • Enzyme-linked immunosorbent assay and multiplex reverse transcription-polymerase chain reaction were used.
  • Stool specimens from 811 children aged 5 years or younger with acute diarrhea were analyzed for five enteric viruses.

Main Results:

  • Rotavirus (25.5%) and norovirus (18.1%) were the most common viral pathogens.
  • Mixed viral infections occurred in 43.5% of cases, frequently involving rotavirus.
  • Rotavirus infections were associated with longer diarrhea duration and higher frequency.

Conclusions:

  • Rotavirus and norovirus are the primary viral etiologies of acute diarrhea in this pediatric cohort.
  • Mixed viral infections are prevalent and rotavirus is a key contributor.
  • Findings highlight the importance of viral surveillance for acute pediatric diarrhea.
Abstract

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