Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Episodic and semantic memory contributions to imagination and creativity.

Memory (Hove, England)·2026
Same author

Reducing type II error in fMRI analysis: cluster-extent threshold simulation results and an evaluation of current methods to correct for multiple comparisons.

Cognitive neuroscience·2026
Same author

Predictive coding of cognitive processes in natural and artificial systems.

Cognitive neuroscience·2025
Same author

Resting-State Functional Connectivity With the Anterior and Posterior Hippocampus: An Analysis of fMRI Data From the Human Connectome Project.

Hippocampus·2025
Same author

False memories activate distinct brain regions in females and males.

Neuroimage. Reports·2025
Same author

Are False Memory and Creative Thinking Mediated by Common Neural Substrates? An fMRI Meta-Analysis.

Creativity research journal·2025
Same journal

Electroacupuncture alleviates neuroinflammation and promotes recovery of neurological functions after intracerebral hemorrhage by modulating α7nAChR/JAK2/STAT3 signaling pathway.

Neuroreport·2026
Same journal

Non-cell-autonomous regulation of Bhlhb5 expression in cortical projection neurons by GABAergic interneuron development and position.

Neuroreport·2026
Same journal

C-C motif chemokine ligand 3 mediates inflammatory response via NLRP3 inflammasome and neuron damage after traumatic brain injury.

Neuroreport·2026
Same journal

Methyltransferase-like 14 alleviates neuronal ferroptosis in Alzheimer's disease by regulating the peroxiredoxin 6/apoptosis signal-regulating kinase 1 signaling pathway.

Neuroreport·2026
Same journal

Hand mental rotation reaction time reflects motor imagery strategy and predicts changes in finger dexterity after motor imagery.

Neuroreport·2026
Same journal

Functional exploration of metabotropic glycine receptors in cultured rat hippocampal slices.

Neuroreport·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

The hippocampus operates in a threshold manner during spatial source memory.

Scott D Slotnick1, Preston P Thakral

  • 1Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02467, USA. sd.slotnick@bc.edu

Neuroreport
|February 15, 2013
PubMed
Summary
This summary is machine-generated.

Recollection in long-term memory may operate differently in the brain than in behavior. The hippocampus shows a threshold process for spatial memory, while behavior suggests a continuous process.

More Related Videos

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Related Experiment Videos

Last Updated: May 14, 2026

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Memory Research

Background:

  • Long-term memory involves familiarity (continuous) and recollection (debated nature).
  • Understanding recollection's neural basis is crucial for memory research.

Purpose of the Study:

  • Investigate if the hippocampus functions in a threshold or continuous manner during recollection.
  • Utilize functional MRI to analyze hippocampal activity patterns in spatial source memory tasks.

Main Methods:

  • Participants studied abstract shapes' locations (left/right).
  • Test phase involved classifying shapes as old-left, old-right, or new with confidence ratings.
  • Functional MRI (fMRI) recorded brain activity, specifically in the hippocampus.

Main Results:

  • Accurate spatial memory for 'old-left' shapes showed a distinct activation in the left hippocampus.
  • Hippocampal activity exhibited a threshold: 'sure' responses for 'old-left' shapes triggered positive activity.
  • Receiver Operating Characteristic (ROC) analysis supported a threshold model for hippocampal recollection, not a continuous one.

Conclusions:

  • The hippocampus may operate via a threshold mechanism in spatial source memory.
  • Behavioral data, however, aligns with a continuous model of recollection.
  • This suggests a transformation of discrete hippocampal signals into continuous behavioral output by other brain regions.