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Related Experiment Video

Updated: May 14, 2026

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

Published on: April 12, 2018

Hemangioblastomas and neurogenic polyglobulia.

Sven Gläsker¹, Marie T Krüger, Jan-Helge Klingler

¹Department of Neurosurgery, Freiburg University Medical Center, Freiburg, Germany. sven.glaesker@uniklinik-freiburg.de

|February 15, 2013

Summary

Neurogenic polyglobulia, a condition causing elevated red blood cells, is linked to central nervous system hemangioblastomas. Tumor removal permanently resolves this polyglobulia, often associated with VHL gene mutations.

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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

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Last Updated: May 14, 2026

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

Published on: April 12, 2018

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Area of Science:

Neuro-oncology
Hematology
Molecular Genetics

Background:

Neurogenic polyglobulia is associated with central nervous system hemangioblastomas.
Potential mechanisms include extramedullary hematopoiesis and von Hippel-Lindau (VHL) gene mutations.

Purpose of the Study:

Determine the frequency of polyglobulia in CNS hemangioblastomas.
Investigate the underlying mechanisms of polyglobulia in these tumors.

Main Methods:

Retrospective analysis of hemoglobin levels in 164 patients with hemangioblastomas (1996-2009).
Pre- and postoperative hemoglobin levels assessed at 3 and 12 months.
Molecular genetic analysis for VHL gene mutations.

Main Results:

Elevated hemoglobin levels (polyglobulia) were observed in a subset of patients.
Surgical removal of hemangioblastomas led to a permanent cure of polyglobulia.
VHL gene mutations were identified in most patients with pathological hemoglobin elevation.

Conclusions:

Neurogenic polyglobulia occurs in a subset of hemangioblastoma patients, particularly VHL mutation carriers.
Tumor removal offers a permanent cure for polyglobulia.
Polyglobulia may result from tumor-induced paraneoplasia or extramedullary hematopoiesis.