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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

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Deep stromal opacity after corneal cross-linking.

Naoko Kato¹, Kenji Konomi, Megumi Saiki

¹Department of Ophthalmology, National Defense Medical College, Saitama, Japan. nkato@ndmc.ac.jp

|February 15, 2013

Summary

This summary is machine-generated.

Deep stromal opacity developed months after uneventful corneal cross-linking (CXL) in three patients. Postoperative inflammation is a potential cause of this delayed stromal opacity following CXL for keratoconus.

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Area of Science:

Ophthalmology
Corneal Surgery
Biomaterials Science

Background:

Corneal cross-linking (CXL) is a standard treatment for progressive keratoconus.
The Dresden protocol is a widely used method for CXL.
Delayed complications after CXL require thorough investigation.

Observation:

Three patients developed deep corneal stromal opacity months post-CXL.
Opacity appeared in the inferior paracentral cornea and persisted for 6-12 months.
Epithelial healing was prompt, and initial stromal infiltration resolved within a week.

Findings:

Deep stromal opacity emerged several months after uneventful CXL procedures.
The opacity did not affect visual acuity as it was not in the visual axis.
Corneal topography and endothelial cell counts were monitored post-procedure.

Implications:

Postoperative inflammation may be implicated in the pathogenesis of delayed stromal opacity.
Ophthalmologists should be aware of this potential delayed complication after CXL.
Further research is needed to elucidate the exact mechanisms and management of this condition.