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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
What is Biodiversity?01:19

What is Biodiversity?

Biodiversity describes the variety of living things at multiple organizational levels: genetic, species and ecosystem diversity. Species diversity includes all branches of the evolutionary tree from single-celled prokaryotic organisms, bacteria, and archaea, to the eukaryotic kingdoms: plants; animals; fungi; and protists. To date, there have been about 1.75 million species identified, and new species are discovered every week.
Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...
Frequency-dependent Selection01:21

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

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Related Experiment Video

Updated: May 14, 2026

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Biodiversity decreases disease through predictable changes in host community competence.

Pieter T J Johnson1, Daniel L Preston, Jason T Hoverman

  • 1Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309, USA. pieter.johnson@colorado.edu

Nature
|February 15, 2013
PubMed
Summary

Higher host biodiversity reduces disease spread. Diverse ecosystems feature more resistant species, lowering pathogen transmission and amphibian disease risk by 78.4%.

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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

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Last Updated: May 14, 2026

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Area of Science:

  • Ecology
  • Disease Ecology
  • Conservation Biology

Background:

  • Rising species extinctions and disease emergence highlight the need to understand biodiversity's impact on disease.
  • Previous studies suggest a negative correlation between host biodiversity and disease risk, but the link between host competence and community assembly is unclear.

Purpose of the Study:

  • To investigate the relationship between host diversity, community composition, and the transmission of the pathogen *Ribeiroia ondatrae* in amphibians.
  • To determine if biodiversity conservation can mitigate disease risk in wildlife populations.

Main Methods:

  • Integrated high-resolution field data from 345 wetlands with multi-scale laboratory and mesocosm experiments.
  • Surveyed 24,215 amphibian hosts to assess species richness, community composition, and pathogen transmission.
  • Conducted controlled experiments manipulating host diversity to measure pathogen transmission and disease pathology.

Main Results:

  • Amphibian species richness was linked to nonrandom changes in community composition, with more competent hosts in species-poor and more resistant species in diverse assemblages.
  • Increased amphibian species richness significantly reduced pathogen transmission by 78.4% and disease pathology.
  • Experimental manipulations showed a ~50% decrease in pathogen transmission and host pathology across a diversity gradient, even when controlling for host density.

Conclusions:

  • Biodiversity, specifically host species richness, consistently influences community competence and inhibits pathogen transmission.
  • These findings support the hypothesis that biodiversity loss can increase disease risk and emphasize the importance of a community-based approach to disease ecology.
  • Conserving biodiversity offers a potential strategy for reducing wildlife disease prevalence and impact.