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Molecular circuits in thrombosis and inflammation

Charles T Esmon1

  • 1Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, 825 NE 13th Street, Oklahoma City, OK 73104, USA. esmonc@omrf.org

Thrombosis and Haemostasis
|February 15, 2013
PubMed
Summary

Histones, particularly H4, drive thrombosis by activating platelets and inhibiting thrombomodulin. Blocking histone activity offers a potential therapeutic strategy for various inflammatory and injury-related conditions.

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