Related Experiment Video
Updated: May 14, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Sibship size, birth order, family structure and childhood mental disorders
Juan J Carballo1, Rebeca García-Nieto, Raquel Alvarez-García
1Department of Psychiatry, Jimenez Diaz Foundation, The Fundación Jiménez Díaz Institute for Medical Research (IIS-FJD). Universidad Autónoma de Madrid (UAM), Avenida Reyes Catolicos 2, 28040, Madrid, Spain. jjcarballo@fjd.es
Insights
Being the middle child and living with both parents may protect against childhood emotional disorders (ED) and attention deficit hyperactivity disorder (ADHD). Large families may increase risks for conduct disorder (CD), mental retardation (MR), and pervasive developmental disorder (PDD).
Area of Science:
- Child Psychology
- Developmental Psychiatry
- Family Studies
Background:
- Childhood mental disorders are a significant public health concern.
- Understanding risk factors is crucial for early intervention and prevention strategies.
- Family dynamics, including birth order and size, may influence child development.
Purpose of the Study:
- To investigate the influence of birth order, sibship size, and family structure on the risk of developing common childhood mental disorders.
- To identify specific family-related factors associated with emotional disorders (ED), attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), mental retardation (MR), and pervasive developmental disorder (PDD).
Main Methods:
- A large-scale case-control study involving 16,823 subjects was conducted in Madrid, Spain (1980-2008).
- Data were collected from individuals diagnosed at public mental health centers.
- Multiple logistic regression analysis was employed to assess the independent associations between family factors and specific diagnoses.
Main Results:
- Birth order and family structure were significant predictors for the risk of ED and ADHD.
- Sibship size and sex were identified as predictors for the risk of childhood mental disorders overall.
- Specific findings indicated that being a middle child and living with both biological parents were associated with a lower risk.
Conclusions:
- Being the middle child and residing in a two-biological-parent household appear to be protective factors against ED and ADHD.
- Larger family sizes were associated with an increased risk for CD, MR, and PDD diagnoses.
- Further research is recommended to explore these complex relationships and inform clinical practice.
Purpose:
The aim of this study was to determine the role that birth order, sibship size and family structure have as risk factors in the development of common childhood mental disorders.
Method:
A case-control study design was conducted (N = 16,823). The group under study consisted of all those subjects who had consulted with a psychiatrist/psychologist and had received a clinical diagnosis at public mental health centres within the Region of Madrid (Spain), between 1980 and 2008. A multiple logistic regression was used to explore the independent association with each diagnosis: emotional disorders (ED) with onset specific to childhood, attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), mental retardation (MR), and pervasive developmental disorder (PDD).
Results:
Birth order and family structure significantly predicted the risk of being diagnosed with ED or ADHD. In addition, sibship size and sex predicted the risk of being diagnosed with a childhood mental disorder.
Conclusions:
We concluded that being the middle child and living with both biological parents appear to be protective factors against the development of ED or ADHD. Living in large families appears to increase the risk of receiving a CD, MR, or PDD diagnosis. Further research is warranted.
More Related Videos
07:56Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
Published on: September 19, 2019
13:08Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
Related Concept Videos
Relationship with Other Adult Family Members and Siblings
Psychological and Sociocultural Causes of Schizophrenia
Sex Linked Disorders
Pedigree Analysis
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Oppositional Defiant Disorder
Diagnostic Criteria and...