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[Familial nonneoplastic inappropriate thyrotropin secretion].
1Medizinische Klinik und Poliklinik, Universität des Saarlandes, Homburg/Saar.
Deutsche Medizinische Wochenschrift (1946)
|May 25, 1990
Summary
This study details a rare familial case of inappropriate thyroid-stimulating hormone (TSH) secretion. Treatment with triiodothyroacetic acid (TRIAC) partially reduced elevated TSH levels, suggesting a potential therapeutic option.
Area of Science:
- Endocrinology
- Oncology
- Genetics
Background:
- A 62-year-old woman presented with suspected follicular thyroid carcinoma following multiple goiter excisions.
- The patient had a history of non-neoplastic inappropriate thyrotropin secretion, a condition characterized by elevated thyroid-stimulating hormone (TSH) levels despite normal or high thyroid hormone levels.
Observation:
- Histological examination could not definitively exclude a small follicular adenoma.
- Previous attempts at TSH suppression using L-thyroxine, triiodothyronine, D-thyroxine with L-thyroxine, and bromocriptine were unsuccessful.
- The patient's TSH levels remained maximally elevated despite various treatments.
Findings:
- Treatment with triiodothyroacetic acid (TRIAC) resulted in a lasting, albeit partial, decrease in maximally elevated TSH levels.
- The patient's daughter also exhibited non-neoplastic inappropriate TSH secretion and had undergone two goiter excisions, indicating a likely familial pattern.
Implications:
- This case highlights the potential efficacy of TRIAC in managing TSH-related disorders.
- The familial occurrence suggests a genetic basis for inappropriate TSH secretion, warranting further investigation into its inheritance patterns.
- Understanding the genetic and molecular mechanisms of this condition is crucial for developing targeted therapies and improving patient outcomes.