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Updated: May 14, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
Published on: August 13, 2013
Induction, control, and plasticity of Treg cells: the immune regulatory network revised?
Vincenzo Barnaba1, Valeria Schinzari
1Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy. vincenzo.barnaba@uniroma1.it
Abstract:
Treg cells expressing the Foxp3 transcription factor play a key role in several aspects of immunological tolerance and in the establishment of immune homeostasis. Here, we discuss the mechanisms, including new evidence on the signals required by Tconv cells to convert into Treg cells described by Yao and colleagues [Eur. J. Immunol. 2013. 43: 458-467] in this issue of European Journal of Immunology, by which Treg-cell dynamics, plasticity and diversification correlate with diverse functions (induction, suppression, contra-suppression) in a variety of settings, such as inflammation, chronic infections, cancer, and autoimmunity.
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