Related Experiment Videos
The effects of TMB-8 on acetylcholine release from frog motor nerve: interactions with adenosine
J M Hunt1, E M Silinsky, J K Hirsh
1Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.
European Journal of Pharmacology
|March 27, 1990
Abstract:
The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.