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Updated: May 14, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Pulmonary aspergilloma
Biljana Lazovic1, Zoran Stajic, Biljana Putnikovic
1Clinical Hospital Centre Zemun, Department of Internal Medicine, Belgrade, Serbia. lazovic.biljana@gmail.com
Introduction:
Aspergillosis is a serious pathologic condition caused by Aspergillus organisms and is frequently seen in immunocompromised patients. Aspergillus species causes a variety of pulmonary diseases such as saphrophyticus (aspergilloma/mycetoma), hypersensitivity reaction (allergic bronhopulmonary), semi- invasive (chronic necrotizing) and angioinvasive aspergillosis.
Case Report:
We report a case of pulmonary aspergilloma (PA) in 38 years old patient who was previously healthy with complaints of fever and hemoptysis. PA was diagnosed radiologically and confirmed by serology.
Conclusion:
Oral itraconazole was administered. The patient responded well to the treatment with improvement in his systemic symptoms and regression of the pulmonary lesions.
Insights
Pulmonary aspergilloma (PA), a fungal infection, can affect healthy individuals. This case study shows successful treatment of PA with oral itraconazole, resolving symptoms and lung lesions.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Pulmonology
Background:
- Aspergillosis is a significant fungal infection caused by Aspergillus species, primarily affecting immunocompromised individuals.
- It manifests in various forms, including aspergilloma, allergic bronchopulmonary aspergillosis, chronic necrotizing aspergillosis, and angioinvasive aspergillosis.
Observation:
- A previously healthy 38-year-old patient presented with fever and hemoptysis, indicative of a pulmonary condition.
- Radiological findings and serological confirmation led to the diagnosis of pulmonary aspergilloma (PA).
Findings:
- The patient received oral itraconazole for the treatment of pulmonary aspergilloma.
- Treatment resulted in significant improvement of systemic symptoms and regression of pulmonary lesions.
Implications:
- This case highlights that pulmonary aspergilloma can occur in seemingly healthy individuals.
- It underscores the efficacy of oral itraconazole as a treatment option for pulmonary aspergilloma, leading to favorable patient outcomes.
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