Pulmonary aspergilloma

Biljana Lazovic1, Zoran Stajic, Biljana Putnikovic

  • 1Clinical Hospital Centre Zemun, Department of Internal Medicine, Belgrade, Serbia. lazovic.biljana@gmail.com

Abstract

Insights

Pulmonary aspergilloma (PA), a fungal infection, can affect healthy individuals. This case study shows successful treatment of PA with oral itraconazole, resolving symptoms and lung lesions.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Aspergillosis is a significant fungal infection caused by Aspergillus species, primarily affecting immunocompromised individuals.
  • It manifests in various forms, including aspergilloma, allergic bronchopulmonary aspergillosis, chronic necrotizing aspergillosis, and angioinvasive aspergillosis.

Observation:

  • A previously healthy 38-year-old patient presented with fever and hemoptysis, indicative of a pulmonary condition.
  • Radiological findings and serological confirmation led to the diagnosis of pulmonary aspergilloma (PA).

Findings:

  • The patient received oral itraconazole for the treatment of pulmonary aspergilloma.
  • Treatment resulted in significant improvement of systemic symptoms and regression of pulmonary lesions.

Implications:

  • This case highlights that pulmonary aspergilloma can occur in seemingly healthy individuals.
  • It underscores the efficacy of oral itraconazole as a treatment option for pulmonary aspergilloma, leading to favorable patient outcomes.

Related Concept Videos

Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...