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Published on: February 10, 2023
Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma
Alexei Shimanovsky1, Constantin A Dasanu
1University of Connecticut, Department of Internal Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA. shimanovsky@resident.uchc.edu
Introduction:
Pralatrexate is a novel antifolate agent that belongs to the class of 10-deazaaminopterins. Its clinical efficacy as a single agent in relapsed or refractory peripheral T-cell lymphoma (PTCL) has been established in randomized trials. Treatment with this agent is generally safe.
Areas Covered:
This paper discusses the pharmacokinetics and efficacy of pralatrexate in T-cell lymphoma in clinical trials. In addition, the authors highlight pralatrexate-associated adverse effects and safety concerns.
Expert Opinion:
Although established as a second-line therapy, pralatrexate offers a clinical benefit to less than one-third of patients with PTCL. In addition, toxicity of this agent can be significant, especially mucositis, immunosuppression and thrombocytopenia. Currently, the potential synergy between pralatrexate and other agents in T-cell lymphoma is being explored in a number of studies. These results will hopefully prove the validity of this approach, leading to improved quantity of life in these patients, with an acceptable comfort index.
