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Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
Acute kidney injury and chronic kidney disease: it's a two-way street
Jason Kline1, Jean-Sebastien Rachoin
1Department of Medicine, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
Abstract:
Acute kidney injury (AKI) is frequently seen in hospitalized patients and its incidence increases with the severity of illness. Recent studies have further illuminated the interdependent relationship between AKI and chronic kidney disease (CKD). CKD and proteinuria have been demonstrated to be risk factors for AKI. Moreover, the previous dogma that prognosis is excellent for patients who recover after AKI episodes may not be universally accurate as CKD is emerging as a long-term consequence after AKI. Short-term mortality is lower in CKD patients with AKI.
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