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Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer
1Department of Radiology, Huashan Hospital of Fudan University, Shanghai, China.
Objective:
The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.
Materials And Methods:
We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.
Results:
Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.
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