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Antinociceptive effect of taurine and its inhibition by naxolone
J S Serrano1, M I Serrano, M R Guerrero
1Department of Pharmacology, Seville University Medical School, Spain.
General Pharmacology
|January 1, 1990
Abstract:
1. We have tested the effect of taurine on nociceptive stimulation provoked by chemical agent (acetic acid) and by the hot-plate test. 2. In the acetic acid test, taurine exerts an antinociceptive effect at every dose and time assayed. The observed effect was dose-related. 3. Naxolone pretreatment antagonizes the antinociceptive effect of taurine in the acetic acid test. 4. The results obtained in hot-plate test show that taurine did not significantly affect latency time for paw licking.