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Related Concept Videos

Carrier-Mediated Transport01:06

Carrier-Mediated Transport

Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport01:19

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...

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Updated: May 14, 2026

Electrochemical Detection of Deuterium Kinetic Isotope Effect on Extracellular Electron Transport in Shewanella oneidensis MR-1
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Electrochemical Detection of Deuterium Kinetic Isotope Effect on Extracellular Electron Transport in Shewanella oneidensis MR-1

Published on: April 16, 2018

Enhanced transport through desorption-mediated diffusion.

Félix Rojo1, Carlos E Budde, Horacio S Wio

  • 1Fa.M.A.F., Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|February 16, 2013
PubMed
Summary
This summary is machine-generated.

We developed a master equation method to analyze bulk-mediated surface diffusion in confined spaces. This approach helps quantify transport efficiency, including escape times and site visits on boundaries.

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Area of Science:

  • Physics
  • Physical Chemistry
  • Materials Science

Background:

  • Surface diffusion is crucial for processes like thin-film growth and catalysis.
  • Understanding diffusion in confined geometries presents unique challenges.
  • Bulk-mediated transport offers an alternative pathway for surface mobility.

Purpose of the Study:

  • To introduce a master equation approach for studying bulk-mediated surface diffusion.
  • To analytically evaluate key parameters characterizing transport efficiency within a confined domain.
  • To provide a framework for understanding surface transport mechanisms in restricted environments.

Main Methods:

  • Development of a master equation model.
  • Analytical evaluation of transport magnitudes.
  • Simulation within a three-dimensional confined domain.

Main Results:

  • The master equation approach successfully characterized bulk-mediated surface diffusion.
  • Analytical expressions were derived for the mean escape time from the domain.
  • The mean number of distinct visited sites on the boundary was calculated.

Conclusions:

  • The master equation provides an effective tool for analyzing bulk-mediated surface diffusion.
  • The method allows for quantitative assessment of transport efficiency in confined systems.
  • This work contributes to the fundamental understanding of surface dynamics in restricted geometries.